VDR is a gene which encodes for a protein that acts as a receptor for vitamin D, which regulates bone development and calcium absorption. A variant of the gene, rs2228570 (FokI polymorphism), is associated with decreased bone mineral density in white prepubescent girls.
The hnRNP C1/C2 component of the nuclear vitamin D receptor complex interacts with promoter regions of genes that are responsive to 1,25-dihydroxyvitamin D3 and can induce their transcription. The interaction is regulated through the reciprocal pattern as well as the temporal off-and-on occupancy of the VDRE between the two components. It is also influenced by chromosomal locations and binding preferences for specific hormones. Microarray studies of human cells show that more than 100 genes carry an identifiable VDRE in their promoters. The VDRE is occupied by transcription repressors in the absence of 1,25-dihydroxyvitamin D3. The 1,25-dihydroxyvitamin D3-VDR complex binds to these genes, resulting in the recruitment of hnRNP C1/C2 and other proteins that can compete with the repressors and initiate transcription.
A virtual dataroom (VDR) is an archive of information and documents that are relevant to legal, business transactions or processes. Viewing, downloading or printing is restricted. It makes use of a central server as well as an extranet connection, which is an Internet connection that has restricted access, to offer restricted access to log-in for specific intervals during which users can access the documents and data.
Companies that deal with investment bankers and in mergers and acquisitions are among the most frequent users of a VDR. They must be able to share information in a transparent manner with potential investors or buyers. Due diligence procedures may also require a huge amount of data. Life science companies also utilize VDRs to store everything from clinical trials results to HIPAA documentation.